Phenotypes Associated with This Genotype

Genotype
MGI:3798054

cn6

• Allelic Composition: Tg(KRT5-cre/PGR)1Der/0; Trp63^tm2Brd/Trp63^tm3.1Brd
• Genetic Background: involves: 129S7/SvEvBrd * FVB * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

early cellular replicative senescence ( J:100483 )

• following treatment with mifepristonein in utero, mice exhibit an increase in cellular senescence

craniofacial

abnormal craniofacial morphology ( J:100483 )

• at E17.5 following treatment with mifepristonein in utero

limbs/digits/tail

abnormal limb morphology ( J:100483 )

• at E17.5 following treatment with mifepristonein in utero

growth/size/body

weight loss ( J:100483 )

• following treatment with mifepristonein at 8 months of age

skeleton

lordokyphosis ( J:100483 )

• following treatment with mifepristonein at 8 months of age, mice exhibit lordokyphosis that increases with severity as mice age

integument

alopecia ( J:100483 )

• following treatment with mifepristonein at 8 months of age, mice exhibit severe alopecia

abnormal skin morphology ( J:100483 )

• at E17.5 following treatment with mifepristonein in utero or at 8 months of age

abnormal epidermal layer morphology ( J:100483 )

• following treatment with mifepristonein utero, mice exhibit stratified epidermal layer and arrested epidermal morphogenesis