Phenotypes Associated with This Genotype

Genotype
MGI:3798055

ht5

• Allelic Composition: Trp63^tm2Brd/Trp63⁺
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:100483 )

• median life span is 95 weeks compared to 121 weeks for wild-type mice

• longevity is decreased 21.5% compared to wild-type mice

premature aging ( J:100483 )

• mice are euthanized due to age-related health issues (skin lesions or infections, weakness, palpable lymph nodes, enlarged abdomen, hemorrhage, rectal prolapse and aberrant circling behavior) earlier than wild-type mice

immune system

enlarged lymph nodes ( J:100483 )

• 19% of of euthanized mice exhibit palpable lymph nodes

kidney inflammation ( J:100483 )

• mice exhibit chronic nephritis

uterine cervix inflammation ( J:100483 )

♀ • mice exhibit vaginal cervicitis

increased susceptibility to infection ( J:100483 )

• mice develop chronic infections if the skin, subcutaneous tissues, oropharynx and genitourinary tract

digestive/alimentary system

abnormal tongue epithelium morphology ( J:100483 )

• mice exhibit lesions in the epithelium of the tongue

• mice exhibit acanthosis of the tongue epithelia

abnormal rectum morphology ( J:100483 )

• mice exhibit lesions in the epithelium of the rectum

rectal prolapse ( J:100483 )

• 6% of euthanized mice exhibit rectal prolapse

cardiovascular system

hemorrhage ( J:100483 )

• 12% of euthanized mice exhibit visible signs of hemorrhage

reproductive system

uterine cervix inflammation ( J:100483 )

♀ • mice exhibit vaginal cervicitis

abnormal uterine cervix epithelium morphology ( J:100483 )

♀ • mice exhibit lesions in the epithelium of the cervix

renal/urinary system

kidney inflammation ( J:100483 )

• mice exhibit chronic nephritis

growth/size/body

abnormal tongue epithelium morphology ( J:100483 )

• mice exhibit lesions in the epithelium of the tongue

• mice exhibit acanthosis of the tongue epithelia

distended abdomen ( J:100483 )

• 14% of euthanized mice exhibit enlarged abdomen

behavior/neurological

weakness ( J:100483 )

• 35% of euthanized mice exhibit extreme weakness

circling ( J:100483 )

• 2% of euthanized mice exhibit aberrant circling

vision/eye

abnormal cornea epithelium morphology ( J:100483 )

• mice exhibit lesions in the epithelium of the cornea of the eye

• mice exhibit corneal granulation

craniofacial

abnormal tongue epithelium morphology ( J:100483 )

• mice exhibit lesions in the epithelium of the tongue

• mice exhibit acanthosis of the tongue epithelia

integument

alopecia ( J:100483 )

• mice exhibit moderate alopecia

acanthosis ( J:100483 )

• mice exhibit acanthosis of the tongue epithelia

skin lesions ( J:100483 )

• 52% of euthanized mice exhibit skin lesions or infections mice exhibit hyperplastic epithelila and progressive skin lesions

spontaneous skin ulceration ( J:100483 )

• mice exhibit ulcerations with severe abscesses in the dermis that often contain bacterial inclusions