Analysis Tools
homeostasis/metabolism
|
• streptozotocin (STZ) treatment leads to 3-fold higher level of blood glucose in mice fed a high fat diet
• these high glucose levels persist for at least 12 weeks after STZ treatment
|
|
• streptozotocin (STZ) induced diabetes in mice fed a high fat diet leads to blood cholesterol levels that are twice those of non-diabetic mice 6 weeks post-induction
• blood cholesterol levels increase to three times greater than in non-diabetic mice 8 weeks after STZ treatment
|
cardiovascular system
|
• non-diabetic mice fed a high fat diet have a total lesion area of 10.7% in their aortas compared to 8.0% in Ldlr tm1Her homozyogotes that do not carry the transgene
• diabetic mice fed a high fat diet for 6 weeks have a total aortic lesion area of 37.5% compared to 23.4% lesion area in diabetic Ldlr tm1Her homozyogotes that do not carry the transgene
• these differences in aortic lesion area between transgenic and non-transgenic Ldlr tm1Her homozyogotes increase the longer the mice are on a high fat diet
• the greatest differences are observed in the aortic arch of diabetic mice where there is a 65% increase in the lesion area 6 weeks after disease induction compared to Ldlr tm1Her homozyogotes that do not carry the transgene
|
immune system
|
• peritoneal macrophages have a higher uptake of acetylated LDL compared macrophages from Ldlr tm1Her homozyogotes that do not carry the transgene
• mean uptake of acetylated-LDL is 5.27 micrograms/mg cellular protein vs 1.18 micrograms/mg cellular protein in controls
|
hematopoietic system
|
• peritoneal macrophages have a higher uptake of acetylated LDL compared macrophages from Ldlr tm1Her homozyogotes that do not carry the transgene
• mean uptake of acetylated-LDL is 5.27 micrograms/mg cellular protein vs 1.18 micrograms/mg cellular protein in controls
|
