Analysis Tools
homeostasis/metabolism
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• streptozotocin (STZ) treatment leads to 3-fold higher level of blood glucose in mice fed a high fat diet
• these high glucose levels persist for at least 12 weeks after STZ treatment
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cardiovascular system
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• in mice made diabetic by STZ treatment and fed a cholesterol/cholic acid containing diet for 12 weeks, total aortic lesion area is doubled compared to Ldlr tm1Her heterozygotes that do not carry the transgene
• the presence of the transgene causes no difference in lesion size in non-diabetic mice
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