Phenotypes for Dmd MGI:3798606 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Dmd^mdx-3Cv/Y
Genetic Background	involves: C3H/HeHa * C57BL/6Ros * C57BL/10Sn * M. m. castaneus * M. m. musculus

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmd^mdx-3Cv mutation (1 available); any Dmd mutation (154 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

skeletal muscle fiber degeneration ( J:9638 )

• mice exhibit skeletal muscle fiber degeneration

impaired muscle relaxation ( J:9638 )

• electromyograms reveal peudomyotonia unlike in wild-type mice

cardiovascular system

cardiac fibrosis ( J:9638 )

• unlike wild-type, some cardiac fibrosis is observed

vision/eye

abnormal eye electrophysiology ( J:23375 )

• although the a-wave amplitude is normal, the b-wave is attenuated by more than 50%

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
Becker muscular dystrophy	DOID:9883	OMIM:300376	J:23375
Duchenne muscular dystrophy	DOID:11723	OMIM:310200	J:23375

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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