cardiovascular system
|
• despite defects in conduction, mice do not exhibit cardiac fibrosis or cellular hypertrophy in cardiac tissues
• heart rate and ventricular repolarization, reflected on the mouse ECG by the ST interval, are similar to controls
|
|
• decreased amplitude and prolonged duration
|
|
• prolonged
|
|
• sodium current is decreased compared to in wild-type cardiomyocytes
|
muscle
|
• compared with wild-type mice
|
|
• mice exhibit reduced muscle contractile function compared with wild-type mice
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Duchenne muscular dystrophy | DOID:11723 |
OMIM:310200 |
J:124861 |