Phenotypes Associated with This Genotype

Genotype
MGI:3798856

tg2

• Allelic Composition: Tg(Mt1)174Bri/Tg(Mt1)174Bri
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestinal mineral absorption ( J:47419 )

• 2 hours after oral dosing with zinc, mice have about a 2-fold less zinc concentration in the blood than in control mice

homeostasis/metabolism

abnormal response to cardiac infarction ( J:85798 )

• the mean percentage of apoptotic cells present in the myocardium after ischemia/reperfusion is 14.4% compared to 26.3%

• myocardial oxidative damage is reduced by almost two-thirds as measured by levels of lipid peroxidation found in the heart after ischemia/reperfusion

decreased myocardial infarct size ( J:85798 )

• only small scattered infarct zones are present after ischemia/reperfusion-induced myocardial infarction

• area of tissue with infarctions visible is only about half that of non-transgenic controls

cardiovascular system

abnormal response to cardiac infarction ( J:85798 )

• the mean percentage of apoptotic cells present in the myocardium after ischemia/reperfusion is 14.4% compared to 26.3%

• myocardial oxidative damage is reduced by almost two-thirds as measured by levels of lipid peroxidation found in the heart after ischemia/reperfusion

decreased myocardial infarct size ( J:85798 )

• only small scattered infarct zones are present after ischemia/reperfusion-induced myocardial infarction

• area of tissue with infarctions visible is only about half that of non-transgenic controls