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Phenotypes Associated with This Genotype
Genotype
MGI:3798942
cx5
Allelic
Composition		 Il2rbtm1Mak/Il2rbtm1Mak
Lcktm1Mak/Lcktm1Mak
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rbtm1Mak mutation (5 available); any Il2rb mutation (45 available)
Lcktm1Mak mutation (1 available); any Lck mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal maternal decidual layer morphology ( J:134589 )
• the decidual region is deficient in normal decidual cells and appears as a large area of adipose tissue
absent uterine NK cells ( J:134589 )
• uterine NK cells are virtually absent in the uteri of pregnant mice at day 14 of gestation
abnormal endometrium morphology ( J:134589 )
• the metrial gland and uterine NK cells are absent from the uteri of pregnant mice at day 14 of gestation
absent endometrial glands ( J:134589 )
• the metrial gland is absent from the uteri of pregnant mice at day 14 of gestation

immune system
absent uterine NK cells ( J:134589 )
• uterine NK cells are virtually absent in the uteri of pregnant mice at day 14 of gestation

embryo
abnormal maternal decidual layer morphology ( J:134589 )
• the decidual region is deficient in normal decidual cells and appears as a large area of adipose tissue
absent uterine NK cells ( J:134589 )
• uterine NK cells are virtually absent in the uteri of pregnant mice at day 14 of gestation

hematopoietic system
absent uterine NK cells ( J:134589 )
• uterine NK cells are virtually absent in the uteri of pregnant mice at day 14 of gestation

endocrine/exocrine glands
absent uterine NK cells ( J:134589 )
• uterine NK cells are virtually absent in the uteri of pregnant mice at day 14 of gestation
absent endometrial glands ( J:134589 )
• the metrial gland is absent from the uteri of pregnant mice at day 14 of gestation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory