Phenotypes Associated with This Genotype

Genotype
MGI:3799096

hm4

• Allelic Composition: Rela^tm1Bal/Rela^tm1Bal
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:28390 )

• after E14 mice begin to die and none survive to birth

liver/biliary system

increased hepatocyte apoptosis ( J:28390 )

• liver degeneration is associated with increased apoptosis of liver cells

liver degeneration ( J:28390 )

• E15 to E16, mice exhibit liver degeneration that specifically targets hepatocytes leaving hematopoietic precursors and red blood cells intact

• liver degeneration is associated with increased apoptosis of liver cells

cardiovascular system

internal hemorrhage ( J:28390 )

• at E16, surviving mice exhibit massive abdominal hemorrhage

cellular

increased hepatocyte apoptosis ( J:28390 )

• liver degeneration is associated with increased apoptosis of liver cells