Phenotypes Associated with This Genotype

Genotype
MGI:3799098

hm3

• Allelic Composition: Rela^tm1Bal/Rela^tm1Bal
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal trigeminal nerve morphology ( J:119844 )

• at E14, the number of neurons in the trigeminal ganglia is decrease compared to in wild-type mice

abnormal neuron physiology ( J:119844 )

• survival following treatment of sensory neurons with NGF is lower than for similarly treated wild-type neurons due to increased apoptosis

• however, sensory neurons exhibit normal survival response to BDNF

increased neuron apoptosis ( J:119844 )

• apoptosis in the trigeminal ganglia of E14 mice is increased compared to in wild-type mice

cellular

abnormal cell death ( J:28390 )

• embryonic fibroblasts treated with mTNF-alpha exhibit decreased survival compared to similarly treated cells

increased neuron apoptosis ( J:119844 )

• apoptosis in the trigeminal ganglia of E14 mice is increased compared to in wild-type mice

immune system

immune system phenotype ( J:113514 )

N • mice exhibit normal dendritic cell development and maturation

decreased marginal zone B cell number ( J:65246 )

• when cells are used to reconstitute a Rag2 null mouse, the number of marginal zone B cells is reduced to one third of normal

hematopoietic system

decreased marginal zone B cell number ( J:65246 )

• when cells are used to reconstitute a Rag2 null mouse, the number of marginal zone B cells is reduced to one third of normal