Analysis Tools
mortality/aging
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• despite normal appearance up to E12, all mice are dead by E14
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hematopoietic system
| N |
• despite impaired erythropoeisis, hematopoietic development potential is normal
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• increased apoptosis during monocyte differentiation in culture results in a reduced frequency of granulocyte and macrophage colonies compared to cultures from wild-type mice
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• 2.5-fold compared to in wild-type mice
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• mice and irradiated wild-type mice transplanted with mutant mice bone marrow exhibit impaired erythropoiesis
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• irradiated mice reconstituted with mutant bone marrow exhibit granulocytosis of fetal liver cells
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liver/biliary system
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• most mice exhibit fetal liver cell apoptosis by E13.5
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cardiovascular system
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• most mice exhibit abdominal hemorrhage by E13.5
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immune system
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• increased apoptosis during monocyte differentiation in culture results in a reduced frequency of granulocyte and macrophage colonies compared to cultures from wild-type mice
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• irradiated mice reconstituted with mutant bone marrow exhibit granulocytosis of fetal liver cells
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cellular
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• most mice exhibit fetal liver cell apoptosis by E13.5
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• increased apoptosis during monocyte differentiation in culture results in a reduced frequency of granulocyte and macrophage colonies compared to cultures from wild-type mice
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