Phenotypes Associated with This Genotype

Genotype
MGI:3799316

• Allelic Composition: Ankrd26^Gt(XK525)Byg/Ankrd26^Gt(XK525)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ankrd26^Gt(XK525)Byg/Ankrd26^Gt(XK525)Byg mice (right) are extremely large and obese

growth/size/body

increased heart weight ( J:130984 )

increased lean body mass ( J:130984 )

increased body weight ( J:130984 )

• both female and male mutant mice gained 1 or 2 g a week up through 4 months of age

obese ( J:130984 )

• adult homozygous mice became extremely large and obese

increased body length ( J:130984 )

increased kidney weight ( J:130984 )

adipose tissue

increased brown adipose tissue amount ( J:130984 )

increased white adipose tissue amount ( J:130984 )

increased fat cell size ( J:130984 )

renal/urinary system

increased kidney weight ( J:130984 )

cardiovascular system

increased heart weight ( J:130984 )

homeostasis/metabolism

increased circulating insulin level ( J:130984 )

increased circulating leptin level ( J:130984 )

increased circulating free fatty acids level ( J:130984 )

• elevated in 8- to 10-month-old mice

increased circulating triglyceride level ( J:130984 )

• elevated in 8- to 10-month-old mice

abnormal energy expenditure ( J:130984 )

• total and resting energy expenditure was significantly higher in mutant mice

• when the data was normalized to lean mass, mutant female are still hypermetabolic

• when the data was normalized to lean mass, the mutant male and wild-type had a similar metabolic rate

insulin resistance ( J:130984 )

• confirmed by an insulin tolerance test

behavior/neurological

polyphagia ( J:130984 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:130984