Phenotypes Associated with This Genotype

Genotype
MGI:3799519

• Allelic Composition: Tg(K6ODCtr)55Tgo/0
• Genetic Background: C57BL/6-Tg(K6ODCtr)55Tgo/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased subcutaneous adipose tissue amount ( J:62356 )

• in older mice, dermal cysts replace the subcutaneous fat layer

growth/size/body

decreased body weight ( J:62356 )

• at birth

dermal cyst ( J:62356 )

• cysts replace the lower portion of the hair follicle

• some cysts have thick walls of stratified squamous epithelium filled with concentrically oriented cornified squames

• in older mice, dermal cysts replace the subcutaneous fat layer

• some cysts rupture and form foreign body granulomas

endocrine/exocrine glands

sebaceous gland hyperplasia ( J:62356 )

• sebaceous glands are moderately hyperplastic

integument

decreased subcutaneous adipose tissue amount ( J:62356 )

• in older mice, dermal cysts replace the subcutaneous fat layer

sebaceous gland hyperplasia ( J:62356 )

• sebaceous glands are moderately hyperplastic

dermal cyst ( J:62356 )

• cysts replace the lower portion of the hair follicle

• some cysts have thick walls of stratified squamous epithelium filled with concentrically oriented cornified squames

• in older mice, dermal cysts replace the subcutaneous fat layer

• some cysts rupture and form foreign body granulomas

alopecia ( J:62356 )

• by 1.5 months of age, mice exhibit generalized hair loss

• cysts replace the lower portion of the hair follicle

long nails ( J:62356 )

• mice exhibit excessive nail growth

abnormal hair follicle morphology ( J:62356 )

dilated hair follicle infundibulum ( J:62356 )

• mice exhibit a dilatation of the hair follicle infundibulum

hair follicle comedo ( J:62356 )

• mice exhibit comedo-like structures associated with sebaceous glands

hair follicle degeneration ( J:62356 )

• disintegration of the lower portion of the hair follicle

absent vibrissae ( J:62356 )

• by 1.5 months of age

wrinkled skin ( J:62356 )

• as mice age their skin exhibits excessive growth resulting in wrinkling and folding

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atrichia with papular lesions		DOID:0060689	OMIM:209500	J:62356