Analysis Tools
immune system
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• develop inflammatory bowl disease with similar onset, progression, and severity as in littermates heterozygous for both alleles
• elevated acute and chronic inflammatory indices similar to littermates heterozygous for both alleles
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• decrease in the CD8alpha alpha to CD8alpha beta ratio similar to that in mice heterozygous for Tnftm2Gkl alone
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• more pronounced decrease in this subset early in the inflammatory disease process compared to mice heterozygous for Tnftm2Gkl alone
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• decrease in TCRalpha beta CD8alpha alpha and TCRalpha beta CD8alpha alpha CD4 numbers similar to mice heterozygous for Tnftm2Gkl alone
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digestive/alimentary system
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• develop inflammatory bowl disease with similar onset, progression, and severity as in littermates heterozygous for both alleles
• elevated acute and chronic inflammatory indices similar to littermates heterozygous for both alleles
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hematopoietic system
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• decrease in the CD8alpha alpha to CD8alpha beta ratio similar to that in mice heterozygous for Tnftm2Gkl alone
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• more pronounced decrease in this subset early in the inflammatory disease process compared to mice heterozygous for Tnftm2Gkl alone
|
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• decrease in TCRalpha beta CD8alpha alpha and TCRalpha beta CD8alpha alpha CD4 numbers similar to mice heterozygous for Tnftm2Gkl alone
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