Phenotypes Associated with This Genotype

Genotype
MGI:3800659

tg2

• Allelic Composition: Tg(WapMyc)212Bri/0
• Genetic Background: FVB.Cg-Tg(WapMyc)212Bri

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal mammary gland morphology ( J:114568 )

♀ • apoptosis in the mammary gland does not decrease with age

mammary gland duct hyperplasia ( J:114568 )

♀ • ductal cell proliferation rates are higher than in wild-type mice but equivalent to lobule proliferation rates

abnormal mammary gland lobule morphology ( J:114568 )

♀ • lobules contain more cells than in wild-type mice

increased mammary gland tumor incidence ( J:114568 )

• cell proliferation rates within tumors is greater than in hyperplastic mammary tissues

mammary gland hyperplasia ( J:114568 )

♀ • cell proliferation within lobules is increased after 16 weeks of age compared to wild-type mice

♀ • unlike wild-type mice, proliferation rates remain high as mice age

♀ • mice exhibit increased number and size of hyperplastic areas compared to wild-type mice

♀ • cell proliferation of normal cells in tumor containing glands is increased compared to non-tumor containing glands

neoplasm

increased mammary gland tumor incidence ( J:114568 )

• cell proliferation rates within tumors is greater than in hyperplastic mammary tissues

integument

abnormal mammary gland morphology ( J:114568 )

♀ • apoptosis in the mammary gland does not decrease with age

mammary gland duct hyperplasia ( J:114568 )

♀ • ductal cell proliferation rates are higher than in wild-type mice but equivalent to lobule proliferation rates

abnormal mammary gland lobule morphology ( J:114568 )

♀ • lobules contain more cells than in wild-type mice

increased mammary gland tumor incidence ( J:114568 )

• cell proliferation rates within tumors is greater than in hyperplastic mammary tissues

mammary gland hyperplasia ( J:114568 )

♀ • cell proliferation within lobules is increased after 16 weeks of age compared to wild-type mice

♀ • unlike wild-type mice, proliferation rates remain high as mice age

♀ • mice exhibit increased number and size of hyperplastic areas compared to wild-type mice

♀ • cell proliferation of normal cells in tumor containing glands is increased compared to non-tumor containing glands