Analysis Tools
mortality/aging
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• female mice die at less than 4 months of age roughly 2 months after their first pregnancy
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endocrine/exocrine glands
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• involution is abolished and only a mild decrease in alveolar size is observed postparturition
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• mice develop large mammary tumors with lung metastases in 2 of 7 mice regardless of pregnancy status and gender
• tumors are poorly differentiated with extensive hemorrhages, necrosis and codominant histology
• tumors are transplantable with shorter latency than tumors with only one of the transgenes expressing
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• mice exhibit increased mammary gland hyperplasia compared to wild-type females or females carrying only one of the transgenes
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• female mice do not lactate
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neoplasm
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• mice develop large mammary tumors with lung metastases in 2 of 7 mice regardless of pregnancy status and gender
• tumors are poorly differentiated with extensive hemorrhages, necrosis and codominant histology
• tumors are transplantable with shorter latency than tumors with only one of the transgenes expressing
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integument
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• involution is abolished and only a mild decrease in alveolar size is observed postparturition
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• mice develop large mammary tumors with lung metastases in 2 of 7 mice regardless of pregnancy status and gender
• tumors are poorly differentiated with extensive hemorrhages, necrosis and codominant histology
• tumors are transplantable with shorter latency than tumors with only one of the transgenes expressing
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• mice exhibit increased mammary gland hyperplasia compared to wild-type females or females carrying only one of the transgenes
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• female mice do not lactate
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