Phenotypes Associated with This Genotype

Genotype
MGI:3800802

tg3

• Allelic Composition: Tg(WapMyc)212Bri/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:56318 )

• female mice die by 8 months of age

endocrine/exocrine glands

mammary gland alveolar hyperplasia ( J:56318 )

♀ • female mice exhibit enlarged and hyperplastic alveoli at day 14 of pregnancy with poorly differentiated epithelium and numerous dead cells

increased mammary gland tumor incidence ( J:56318 )

• female mice develop mammary gland tumors and die by 8 months of age

• female mice develop solid carcinomas and few glandular/microcystic or papillary adenocarcinomas

• 42% of tumors are mixed glandular and solid or glandular and papillary

• lung metastasis occurs in 3 of 14 mice and tumors are transplantable

• however, virgin females do not develop mammary gland tumors

increased mammary adenocarcinoma incidence ( J:56318 )

• few tumors are adenocarcinomas

lactation failure ( J:56318 )

♀ • female mice do not lactate

neoplasm

increased mammary gland tumor incidence ( J:56318 )

• female mice develop mammary gland tumors and die by 8 months of age

• female mice develop solid carcinomas and few glandular/microcystic or papillary adenocarcinomas

• 42% of tumors are mixed glandular and solid or glandular and papillary

• lung metastasis occurs in 3 of 14 mice and tumors are transplantable

• however, virgin females do not develop mammary gland tumors

increased mammary adenocarcinoma incidence ( J:56318 )

• few tumors are adenocarcinomas

integument

mammary gland alveolar hyperplasia ( J:56318 )

♀ • female mice exhibit enlarged and hyperplastic alveoli at day 14 of pregnancy with poorly differentiated epithelium and numerous dead cells

increased mammary gland tumor incidence ( J:56318 )

• female mice develop mammary gland tumors and die by 8 months of age

• female mice develop solid carcinomas and few glandular/microcystic or papillary adenocarcinomas

• 42% of tumors are mixed glandular and solid or glandular and papillary

• lung metastasis occurs in 3 of 14 mice and tumors are transplantable

• however, virgin females do not develop mammary gland tumors

increased mammary adenocarcinoma incidence ( J:56318 )

• few tumors are adenocarcinomas

lactation failure ( J:56318 )

♀ • female mice do not lactate