Analysis Tools
homeostasis/metabolism
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• 80% reduction in brain 5-HT production
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behavior/neurological
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• in a test of social interaction in a neutral arena, males exhibit enhanced levels of physical attacks against a non-aggressive male
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• immobility times in the tail suspension test are prolonged
(J:131619)
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• mutants exhibit increased immobility in the tail-suspension test compared to wild-type mice
(J:196373)
• fluoxetine treatment decreases immobility in mutants
(J:196373)
• however, no differences in gross locomotor activity are seen and fluoxetine treatment significantly decreases forward locomotion in mutants
(J:196373)
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• in the dark-light emergence test, mutants display longer latencies to cross to the lighted compartment, reduced activity in the lighted compartment, and more transitions between the two compartments compared to controls
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nervous system
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• mutants exhibit increased intra-network synchrony within medial prefrontal cortex and basal amygdala (increase in amygdala-medial prefrontal cortex delta and beta spectral coherence) and increased internetwork synchrony between the two networks (increase in amygdala and medial prefrontal cortex delta-beta cross-frequency phase coupling)
• fluoxetine treatment decreases amygdala-medial prefrontal cortex delta coherence in mutants but has no effect in wild-type mice, however chronic fluoxetine treatment does not have a significant effect on beta coherence and cross-frequency phase coupling
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| melancholic depression | DOID:1595 |
OMIM:608516 |
J:196373 | |
