Phenotypes Associated with This Genotype

Genotype
MGI:3801184

hm3

• Allelic Composition: Sharpin^cpdm/Sharpin^cpdm
• Genetic Background: involves: C57BL/KaLawRij * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

absent spleen B cell follicles ( J:121810 )

• spleens have no defined follicles and germinal centers are absent

absent spleen germinal center ( J:121810 )

absent Peyer's patches ( J:121810 )

• no organized follicular structure are present in the antimesenteric wall of the small intestine

skin inflammation ( J:121810 )

• Background Sensitivity: the FVB/NJ background modifies the phenotype such that the skin shows mild inflammation and scattered apoptotic keratinocytes with a delayed onset

hematopoietic system

absent spleen B cell follicles ( J:121810 )

• spleens have no defined follicles and germinal centers are absent

absent spleen germinal center ( J:121810 )

integument

skin inflammation ( J:121810 )

• Background Sensitivity: the FVB/NJ background modifies the phenotype such that the skin shows mild inflammation and scattered apoptotic keratinocytes with a delayed onset