Analysis Tools
mortality/aging
 |
• 50% lethality by 8 weeks
|
growth/size/body
weight loss
(
J:137513
)
|
|
• marked weight loss starting about 1 week before death
|
|
|
• failure to thrive after 5 weeks
• mean weight 15 g at 8 weeks comppared to 21 g for controls
|
behavior/neurological
|
N |
• general locomotion is normal through 6 weeks of age
|
|
|
• reduced ability to associate foot shock with context
|
|
|
• reduced ability to associate auditory cue to footshock
|
|
|
• as measured on an elevated + maze
|
|
|
• clasping of hind limbs when lifted by the tail
|
|
|
• coordination remains impaired through week 9
(J:137344)
• time spent on an accelerating rotarod about 1/3 that of controls
(J:137513)
• no improvement with successive trials
(J:137513)
|
|
|
• splayed limbs
|
|
|
• less rearing behavior when maintained in a standard environment
|
|
|
• lower activity levels on free wheels in mice before onset of breathing problems or seizures
|
|
|
• episodes of seizures
|
nervous system
|
|
• episodes of seizures
|
respiratory system
|
|
• labored breathing
|
integument
|
|
• erect whiskers
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Rett syndrome | DOID:1206 |
OMIM:312750 OMIM:613454 |
J:137344 | |
