Phenotypes Associated with This Genotype

Genotype
MGI:3801488

• Allelic Composition: Mecp2^tm1Pplt/Mecp2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:137344 )

♀ • motor defect on initial exposure to rotarod test

♀ • rotarod performance normalized when maintained in an "enriched" environment

♀ • rotarod performance improves over 5 days of training

♀ • rotarod performance remains deficient relative to wild-type kept in a standard environment

♀ • coordination improvement acquired with training is lost in the weeks subsequent to training

♀ • "enriched" environment prevents coordination deficiency from developing

decreased vertical activity ( J:137344 )

♀ • reduced rearing activity regardless of the environment

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:137344