Phenotypes Associated with This Genotype

Genotype
MGI:3803116

cn6

• Allelic Composition: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor⁺; Opn4^tm1(cre)Sapa/Opn4⁺
• Genetic Background: involves: 129S * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

impaired pupillary reflex ( J:137151 )

• following treatment with diphtheria toxin, light pupilary reflex is lost

decreased retina ganglion cell number ( J:137151 )

• following treatment with diphtheria toxin, 90% of melanopsin retinal ganglion cells are ablated

nervous system

abnormal suprachiasmatic nucleus morphology ( J:137151 )

• following treatment with diphtheria toxin, projections into the suprachiasmatic nucleus are reduced compared to in wild-type mice

decreased retina ganglion cell number ( J:137151 )

• following treatment with diphtheria toxin, 90% of melanopsin retinal ganglion cells are ablated

behavior/neurological

behavior/neurological phenotype ( J:137151 )

N • despite ablation of melanopsin retinal ganglion cells following treatment with diphtheria toxin, mice exhibit normal image-forming visual responses

impaired pupillary reflex ( J:137151 )

• following treatment with diphtheria toxin, light pupilary reflex is lost

abnormal circardian behavior entrainment ( J:137151 )

• following treatment with diphtheria toxin, mice lose their ability to photo-entrain their circadian rhythm and mice maintain equal activity during light and dark phases unlike in wild-type mice