Phenotypes Associated with This Genotype

Genotype
MGI:3803206

hm11

• Allelic Composition: Lepr^db/Lepr^db
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BLKS/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal kidney morphology ( J:127478 )

• total kidney collagen is increased in females by 96%

abnormal renal glomerulus morphology ( J:127478 )

• glomerular extracellular matrix (ECM) area in females is increased by 31% compared to wild-type female controls and female single Serpine1-deficient animals; however, when expressed as fractional glomerular ECM area, little difference is observed between any genotype