Phenotypes Associated with This Genotype

Genotype
MGI:3803207

cx30

• Allelic Composition: Lepr^db/Lepr^db; Serpine1^tm1Mlg/Serpine1^tm1Mlg
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BLKS/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:127478 )

• 23% of females and 44% of males in the F3 generation died prematurely, of indeterminate cause

growth/size/body

obese ( J:127478 )

• female mice are obese relative to wild-type and Serpine1-deficient single mutant controls

decreased body size ( J:127478 )

• 63% of males in F3 generation are runts with body weight ranging from 20-40 grams compared to 60-100 grams for littermates not displaying runt phenotype

renal/urinary system

albuminuria ( J:127478 )

• present with slightly higher urinary albumin to creatinine ratios relative to Lepr single homozygotes

abnormal kidney morphology ( J:127478 )

• total kidney collagen is increased in females by 47% compared to female single Serpine1-deficient animals

abnormal renal glomerulus morphology ( J:127478 )

• glomerular extracellular matrix (ECM) areas are reduced 10% in females compared to female single Serpine1-deficient animals; however, when expressed as fractional glomerular ECM area, little difference is observed between any genotype

homeostasis/metabolism

increased blood urea nitrogen level ( J:127478 )

• significantly higher BUN levels compared to Serpine1-deficient single mutants

hyperglycemia ( J:127478 )

• hyperglycemia is less severe than observed in Serpine1-sufficient, Lepr-deficient controls at 10, 14, and 34 weeks of age

albuminuria ( J:127478 )

• present with slightly higher urinary albumin to creatinine ratios relative to Lepr single homozygotes

abnormal enzyme/coenzyme activity ( J:127478 )

• total urokinase plasminogen activator (uPA) activity is significantly higher than wild-type compared to Serpine1-sufficient diabetic controls