Phenotypes Associated with This Genotype

Genotype
MGI:3804216

• Allelic Composition: Rb1^tm2Brn/Rb1^tm2Brn; Trp53^tm1Brd/Trp53^tm1Brd; Tg(Gfap-cre)2Brn/0
• Genetic Background: involves: 129 * 129S7/SvEvBrd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased medulloblastoma incidence ( J:61961 )

• mutants develop highly aggressive embryonal tumors of the cerebellum with typical features of medulloblastoma

• tumors are identified as early as 7 weeks of age on the outer surface of the molecular layer, corresponding to the location of the cerebellar external granular layer cells during development

behavior/neurological

tremors ( J:61961 )

ataxia ( J:61961 )

impaired balance ( J:61961 )

• loss of balance

• mutants hold their heads to one side

abnormal gait ( J:61961 )

• gait is disturbed with ataxia

circling ( J:61961 )

nervous system

increased medulloblastoma incidence ( J:61961 )

• mutants develop highly aggressive embryonal tumors of the cerebellum with typical features of medulloblastoma

• tumors are identified as early as 7 weeks of age on the outer surface of the molecular layer, corresponding to the location of the cerebellar external granular layer cells during development

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
medulloblastoma		DOID:0050902	OMIM:155255	J:61961