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Phenotypes Associated with This Genotype
Genotype
MGI:3804217
Allelic
Composition		 Rb1tm2Brn/Rb1tm2Brn
Trp53tm1Brn/Trp53tm1Brn
Tg(Gfap-cre)2Brn/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm2Brn mutation (3 available); any Rb1 mutation (111 available)
Tg(Gfap-cre)2Brn mutation (1 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (239 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased medulloblastoma incidence ( J:61961 )
• mutants develop medulloblastomas

nervous system
increased medulloblastoma incidence ( J:61961 )
• mutants develop medulloblastomas

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
 J:61961

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory