Phenotypes Associated with This Genotype

Genotype
MGI:3804634

cn2

• Allelic Composition: Eomes^tm1Srnr/Eomes^tm1Srnr; Tbx21^tm1Srnr/Tbx21^tm1Srnr; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased neutrophil cell number ( J:137655 )

abnormal T cell morphology ( J:137655 )

abnormal CD8-positive, alpha-beta T cell differentiation ( J:137655 )

• impaired cytotoxic CD8+ T cell differentiation following viral infection

• following viral infection, differentiation is skewed exclusively toward the Type 17 fate

decreased CD8-positive, alpha-beta T cell number ( J:137655 )

• defect in accumulation of CD8+ T cells following viral infection

decreased memory T cell number ( J:137655 )

• deficiency in memory-phenotype CD8+ T cells

abnormal immune system physiology ( J:137655 )

abnormal leukocyte physiology ( J:137655 )

• CD8+ T cells have a severe defect in cytotoxic gene expression in response to viral peptide stimulation even when cellularity is normalized

abnormal interleukin level ( J:137655 )

• increase in IL17 expression in CD8+ T cells in response to stimulation with viral derived peptides

increased susceptibility to Riboviria infection ( J:137655 )

• persistent high titers of lymphocyte choriomeningitis virus

• progressive weight loss, not seen in controls, begins about 1 week after infection and is accompanied by extensive organ pathology and excessive neutrophil response

• depletion of CD8+ T cells prevents viral induced wasting, neutrophilia, and organ pathology

homeostasis/metabolism

abnormal interleukin level ( J:137655 )

• increase in IL17 expression in CD8+ T cells in response to stimulation with viral derived peptides

hematopoietic system

increased neutrophil cell number ( J:137655 )

abnormal T cell morphology ( J:137655 )

abnormal CD8-positive, alpha-beta T cell differentiation ( J:137655 )

• impaired cytotoxic CD8+ T cell differentiation following viral infection

• following viral infection, differentiation is skewed exclusively toward the Type 17 fate

decreased CD8-positive, alpha-beta T cell number ( J:137655 )

• defect in accumulation of CD8+ T cells following viral infection

decreased memory T cell number ( J:137655 )

• deficiency in memory-phenotype CD8+ T cells

abnormal leukocyte physiology ( J:137655 )

• CD8+ T cells have a severe defect in cytotoxic gene expression in response to viral peptide stimulation even when cellularity is normalized