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Phenotypes Associated with This Genotype
Genotype
MGI:3805024
Allelic
Composition
Bard1tm1Thl/Bard1tm2Thl
Waptm1(cre)Arge/0
Genetic
Background
involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bard1tm1Thl mutation (0 available); any Bard1 mutation (55 available)
Bard1tm2Thl mutation (0 available); any Bard1 mutation (55 available)
Waptm1(cre)Arge mutation (0 available); any Wap mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland

integument
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland

endocrine/exocrine glands
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:134977


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory