Phenotypes Associated with This Genotype

Genotype
MGI:3805034

• Allelic Composition: Hps5^ru2-mr/Hps5^ru2-mr
• Genetic Background: B6.Cg-Hps5^ru2-mr/Re

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased platelet ATP level ( J:7327 )

• platelet ATP levels are much lower than in C57BL/6J controls

decreased platelet ADP level ( J:7327 )

• platelet ADP levels are much lower than in C57BL/6J controls

decreased platelet dense granule number ( J:7327 )

• decreased number of platelet dense granules compared with C57BL/6J controls

decreased platelet serotonin level ( J:7327 , J:29748 )

• platelet serotonin levels are less than 7% of normal platelet serotonin levels (J:7327)

• platelet serotonin level is also lower than that of control when fed an atherogenic diet (J:29748)

homeostasis/metabolism

decreased platelet ATP level ( J:7327 )

• platelet ATP levels are much lower than in C57BL/6J controls

decreased platelet serotonin level ( J:7327 , J:29748 )

• platelet serotonin levels are less than 7% of normal platelet serotonin levels (J:7327)

• platelet serotonin level is also lower than that of control when fed an atherogenic diet (J:29748)

increased bleeding time ( J:7327 )

• bleed time averaging over 14 minutes after tail nick is much greater than the 3.8 minutes for C57BL/6J controls

cardiovascular system

decreased susceptibility to atherosclerosis ( J:29748 )

• on an atherogenic diet homozygotes develop fewer and smaller aortic lesions than do C57BL/6J controls

cellular

decreased platelet ATP level ( J:7327 )

• platelet ATP levels are much lower than in C57BL/6J controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
platelet storage pool deficiency		DOID:2223	OMIM:185050	J:7327