Phenotypes Associated with This Genotype

Genotype
MGI:3805694

hm1

• Allelic Composition: Gpr22^tm1.1Jwad/Gpr22^tm1.1Jwad
• Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased response of heart to induced stress ( J:138227 )

• following aortic banding, mice exhibit decreased fractional shortening and decompensated heart failure characterized by chamber dilation and an increase left ventricle end-systolic diameter unlike in similarly treated wild-type mice that exhibit compensated hypertrophy

• however, mice exhibit normal cardiac health under unstressed conditions

homeostasis/metabolism

increased response of heart to induced stress ( J:138227 )

• following aortic banding, mice exhibit decreased fractional shortening and decompensated heart failure characterized by chamber dilation and an increase left ventricle end-systolic diameter unlike in similarly treated wild-type mice that exhibit compensated hypertrophy

• however, mice exhibit normal cardiac health under unstressed conditions