About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3805721
Allelic
Composition
Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gp1bbtm2Frla mutation (1 available); any Gp1bb mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• discoid platelets have enlarged diameter compared to wild-type
• platelets display 2-fold increase in number of microtubules
• platelet counts are reduced by 73%

homeostasis/metabolism
• platelet adhesion from blood at high shear forces (3000 s-1) is nearly abolished (83% decrease) relative to wild-type blood; platelet adhesion and aggregation is 50-60% of wild-type at a shear rate of 1500 s-1
• in vivo, application of FeCl3 produces stable occlusion in 62.5% of arteries after 30 minutes compared to 75% in wild-type; thrombi are less extensive than wild-type with little sign of degranulation
• laser beam-induced superficial lesions of mesenteric arterioles results in thrombi with surface area decreased by 45% compared to wild-type while initial thrombus growth after severe lesion is delayed but reaches comparable size at later times
• 52% of mice bled for more than 20 minutes compared to 82% of wild-type having bleeding times of <12 minutes

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Bernard-Soulier syndrome DOID:2217 OMIM:231200
J:135065


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/05/2024
MGI 6.24
The Jackson Laboratory