Phenotypes Associated with This Genotype

Genotype
MGI:3806486

• Allelic Composition: Lrp5^r18/Lrp5^r18
• Genetic Background: C57BL/6J-Lrp5^r18

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal retina vasculature morphology ( J:135279 )

• hyperpermeable retinal vessels

• reduced density of retinal small vessels and capillaries and an attenuated and abnormally patterned vasculature due to incomplete development

• immature endothelial cells in lumen-less capillaries are associated with an attenuated vessel network

vision/eye

abnormal retina vasculature morphology ( J:135279 )

• hyperpermeable retinal vessels

• reduced density of retinal small vessels and capillaries and an attenuated and abnormally patterned vasculature due to incomplete development

• immature endothelial cells in lumen-less capillaries are associated with an attenuated vessel network

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
exudative vitreoretinopathy		DOID:0050535	OMIM:PS133780	J:135279