Phenotypes Associated with This Genotype

Genotype
MGI:3806713

• Allelic Composition: Rtn4r^tm1Gogo/Rtn4r^tm1Gogo
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:130368 )

N • mice exhibit normal startle response, conditioned fear responses, and working memory in addition to not displaying behavioral despair

N • mice do not display schizophrenia-related behaviors

decreased vertical activity ( J:130368 )

• mice exhibit reduced vertical rearing in an open field test compared to wild-type mice

decreased locomotor activity ( J:130368 )

• mice travel reduced distances in an open field test compared to wild-type mice

• mice treated with an NMDA blocker (MK-801) exhibit decreased locomotor activity compared to similarly treated wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	schizophrenia	DOID:5419	OMIM:181500	J:130368