Phenotypes Associated with This Genotype

Genotype
MGI:3807672

hm1

• Allelic Composition: Tradd^tm1.1Mpa/Tradd^tm1.1Mpa
• Genetic Background: involves: BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal spleen germinal center morphology ( J:139030 )

• impaired formation of follicular dendritic cell networks and germinal centers following immunization with sheep red blood cells

decreased IgG level ( J:139030 )

• produce low titers of sheep red blood cell antibodies after immunization compared to wild-type controls

decreased circulating tumor necrosis factor level ( J:139030 )

• in response to poly(I:C) or LPS injection, compared to controls

• impairment in LPS-induce TNF response is not as severe as in mice homozygous for Myd88^tm1Aki

• however, TNF levels following administration of CpG DNA are similar to controls

abnormal interleukin level ( J:139030 )

• cultured splenocytes and bone marrow-derived dendritic cells produce less IL6 in response to poly(I:C)

increased susceptibility to bacterial infection ( J:139030 )

• increased susceptibility to L. monocytogenes-induced lethality compared to wild-type controls but not as susceptible as mice homozygous for Tnfrsf1a^tm1Mak

homeostasis/metabolism

decreased circulating tumor necrosis factor level ( J:139030 )

• in response to poly(I:C) or LPS injection, compared to controls

• impairment in LPS-induce TNF response is not as severe as in mice homozygous for Myd88^tm1Aki

• however, TNF levels following administration of CpG DNA are similar to controls

abnormal interleukin level ( J:139030 )

• cultured splenocytes and bone marrow-derived dendritic cells produce less IL6 in response to poly(I:C)

decreased physiological sensitivity to xenobiotic ( J:139030 )

• decrease in sensitivity to hepatocyte apoptosis and liver failure induced by a combination of TNF and D-galactosamine

hematopoietic system

abnormal spleen germinal center morphology ( J:139030 )

• impaired formation of follicular dendritic cell networks and germinal centers following immunization with sheep red blood cells

decreased IgG level ( J:139030 )

• produce low titers of sheep red blood cell antibodies after immunization compared to wild-type controls