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Phenotypes Associated with This Genotype
Genotype
MGI:3807673
cx3
Allelic
Composition		 Myd88tm1Aki/Myd88tm1Aki
Traddtm1.1Mpa/Traddtm1.1Mpa
Genetic
Background		 involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myd88tm1Aki mutation (9 available); any Myd88 mutation (52 available)
Traddtm1.1Mpa mutation (0 available); any Tradd mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased circulating tumor necrosis factor level ( J:139030 )
• in response to LPS stimulation
• impairment is more severe than in either single homozygote

homeostasis/metabolism
decreased circulating tumor necrosis factor level ( J:139030 )
• in response to LPS stimulation
• impairment is more severe than in either single homozygote

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory