Phenotypes Associated with This Genotype

Genotype
MGI:3809288

• Allelic Composition: Nphp3^pcy/Nphp3^tm1Cbe
• Genetic Background: involves: C57BL/6 * CD-1 * KK/Upj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal renal tubule epithelial cell primary cilium morphology ( J:139258 )

• epithelial cells have longer monocilia in dilated kidney tubules

kidney cyst ( J:139258 )

• seen as early as 4 weeks after birth

• progressive increase in cyst size and number with age

• present in all mice

dilated renal tubule ( J:139258 )

cellular

abnormal renal tubule epithelial cell primary cilium morphology ( J:139258 )

• epithelial cells have longer monocilia in dilated kidney tubules

growth/size/body

kidney cyst ( J:139258 )

• seen as early as 4 weeks after birth

• progressive increase in cyst size and number with age

• present in all mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
nephronophthisis 3		DOID:0111114	OMIM:604387	J:139258