Phenotypes Associated with This Genotype

Genotype
MGI:3809475

• Allelic Composition: Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz/Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz
• Genetic Background: involves: C57BL/6 * C57BL/10Sn * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell physiology ( J:108635 )

• T cells from mice immunized with human collagen have higher responses to collagen-derived peptides

• in almost all cases, these peptides need to be presented by the transgenic MHC-complex and not the endogenous MHC to elicit a response

increased susceptibility to induced arthritis ( J:108635 )

• mice are highly susceptible to arthritis induced by human collagen with incidence rates between 88% to 100% by 50 days post-injection

• mice have marked swelling and erythema of the hind and fore paws after human collagen administration

• inflammation frequently includes the wrist and ankle with massive infiltration of inflammatory cells leading to erosion of articular surfaces

• littermate control mice do not develop disease when injected human collagen

increased autoantibody level ( J:108635 )

• mice immunized with human collagen produce at least 5-fold more antibody to mouse collagen than do non-transgenic controls

skeleton

increased susceptibility to induced arthritis ( J:108635 )

• mice are highly susceptible to arthritis induced by human collagen with incidence rates between 88% to 100% by 50 days post-injection

• mice have marked swelling and erythema of the hind and fore paws after human collagen administration

• inflammation frequently includes the wrist and ankle with massive infiltration of inflammatory cells leading to erosion of articular surfaces

• littermate control mice do not develop disease when injected human collagen

hematopoietic system

abnormal T cell physiology ( J:108635 )

• T cells from mice immunized with human collagen have higher responses to collagen-derived peptides

• in almost all cases, these peptides need to be presented by the transgenic MHC-complex and not the endogenous MHC to elicit a response

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
rheumatoid arthritis		DOID:7148	OMIM:180300	J:108635