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Phenotypes Associated with This Genotype
Genotype
MGI:3810319
Allelic
Composition		 Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Tlx3tm1(cre)Qima/Tlx3+
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Smo/EYFP)Amc mutation (1 available); any Gt(ROSA)26Sor mutation (992 available)
Tlx3tm1(cre)Qima mutation (0 available); any Tlx3 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:139574 )
• mice survive 102 days

neoplasm
increased medulloblastoma incidence ( J:139574 )
• 40% of mice develop focal medulloblastomas and have a mean survival of 102 days

nervous system
increased medulloblastoma incidence ( J:139574 )
• 40% of mice develop focal medulloblastomas and have a mean survival of 102 days

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
 J:139574

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory