Phenotypes Associated with This Genotype

Genotype
MGI:3810322

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc}/Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc}; Tg(Atoh1-cre/Esr1*)14Fsh/0
• Genetic Background: involves: 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:139574 )

• mice survive 41 days

nervous system

increased medulloblastoma incidence ( J:139574 )

• all mice develop diffuse medulloblastomas and have a mean survival of 41 days

abnormal cerebellum external granule cell layer morphology ( J:139574 )

• mice exhibit hyperplasia on the external granule cell layer beginning at P0 and more prominently at P7

neoplasm

increased medulloblastoma incidence ( J:139574 )

• all mice develop diffuse medulloblastomas and have a mean survival of 41 days

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
medulloblastoma		DOID:0050902	OMIM:155255	J:139574