Phenotypes Associated with This Genotype

Genotype
MGI:3810650

cn8

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Tg(Fabp7-cre,-lacZ)3Gtm/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:139866 )

N • unlike mice homozygous for Nf1^tm1Par and hemizygous for Tg(Fabp7-cre)2Gtm , mice are viable with no reduction in life span

nervous system

nervous system phenotype ( J:139866 )

N • unlike mice homozygous for Nf1^tm1Par and hemizygous for Tg(Fabp7-cre)2Gtm no change in pyramidal neuron apical dendrite length or neuritic development are detected

abnormal brain development ( J:139866 )

• increase in the number of Olig2+ progenitor cells

abnormal hippocampus morphology ( J:139866 )

• an increase in proliferating cells is seen in the CA2/3 region

abnormal CNS glial cell morphology ( J:139866 )

• expansion of glial cells similar to that in mice homozygous for Nf1^tm1Par and hemizygous for Tg(Fabp7-cre)2Gtm

abnormal astrocyte morphology ( J:139866 )

• increase in the number of GFAP+ astrocytes in the brain

growth/size/body

growth/size/body region phenotype ( J:138868 , J:139866 )

N (J:138868)

N • unlike mice homozygous for Nf1^tm1Par and hemizygous for Tg(Fabp7-cre)2Gtm , no growth retardation is seen (J:139866)

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:138868 )

N • unlike mice homozygous for Nf1^tm1Par and hemizygous for Tg(Fabp7-cre)2Gtm , no impairment in pituitary gland development is detected