Phenotypes Associated with This Genotype

Genotype
MGI:3810657

cn1

• Allelic Composition: Ncoa6^tm1Jkr/Ncoa6^tm1Jkr; Tg(MMTV-cre)FMam/?
• Genetic Background: involves: 129P2/OlaHsd * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Retarded ductal branching of Ncoa6^tm1Jkr/Ncoa6^tm1Jkr Tg(MMTV-cre)FMam/? mammary glands during puberty

endocrine/exocrine glands

abnormal mammary gland development ( J:121207 )

♀ • defective mammopoiesis during puberty, pregnancy, and lactation

abnormal branching of the mammary ductal tree ( J:121207 )

♀ • mammary glands show a normal elongation of ducts but a decreased number of ductal branches and reduced density of ducts during puberty and long after puberty

♀ • ductal branching stimulated by direct estrogen treatment of ovariectomized females is attenuated in mutants

abnormal mammary gland growth during lactation ( J:121207 )

♀ • lactating mammary glands contain decreased numbers of lobuloalveoli with many adipoctyes

abnormal mammary gland growth during pregnancy ( J:121207 )

♀ • glands from females on the 15th day of pregnancy show impaired lobuloalveolar development with decreased density of alveoli

abnormal mammary duct terminal end bud morphology ( J:121207 )

♀ • slight increase in apoptosis is seen in the terminal end buds of mutant inguinal mammary glands

hypolactation ( J:121207 )

♀ • most pups from mutant litters die within 48 hours after birth with no milk in stomachs, however pups can be fostered by wild-type females, indicating inability to produce a sufficient amount of milk to nurse pups

reproductive system

abnormal mammary gland growth during pregnancy ( J:121207 )

♀ • glands from females on the 15th day of pregnancy show impaired lobuloalveolar development with decreased density of alveoli

integument

abnormal mammary gland development ( J:121207 )

♀ • defective mammopoiesis during puberty, pregnancy, and lactation

abnormal branching of the mammary ductal tree ( J:121207 )

♀ • mammary glands show a normal elongation of ducts but a decreased number of ductal branches and reduced density of ducts during puberty and long after puberty

♀ • ductal branching stimulated by direct estrogen treatment of ovariectomized females is attenuated in mutants

abnormal mammary gland growth during lactation ( J:121207 )

♀ • lactating mammary glands contain decreased numbers of lobuloalveoli with many adipoctyes

abnormal mammary gland growth during pregnancy ( J:121207 )

♀ • glands from females on the 15th day of pregnancy show impaired lobuloalveolar development with decreased density of alveoli

abnormal mammary duct terminal end bud morphology ( J:121207 )

♀ • slight increase in apoptosis is seen in the terminal end buds of mutant inguinal mammary glands

hypolactation ( J:121207 )

♀ • most pups from mutant litters die within 48 hours after birth with no milk in stomachs, however pups can be fostered by wild-type females, indicating inability to produce a sufficient amount of milk to nurse pups