Phenotypes Associated with This Genotype

Genotype
MGI:3811268

tg1

• Allelic Composition: Tg(Sftpc-Mirn17-92)1Blh/0
• Genetic Background: involves: FVB * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:128019 )

• 7 of 27 mice were born dead with very abnormal lungs

respiratory system

abnormal lung morphology ( J:128019 )

• in all mice

pulmonary hyperplasia ( J:128019 )

• mice exhibit lung hypercellularity due to a 4-fold increased in proliferation in the lungs

• the lungs of mice that die at birth exhibit a 3-fold increase in the number of neuroendocrine cell clusters in their lungs compared to in wild-type mice

abnormal lung development ( J:128019 )

• at P0, epithelial progenitor cells persist in the lungs unlike in wild-type mice

• differentiation of proximal cells is delayed compared to in wild-type mice

abnormal pulmonary alveolus morphology ( J:128019 )

• at E18.5, the number of alveoli is decreased compared to in wild-type mice and are packed with numerous epithelial cells

atelectasis ( J:128019 )

• no air is found within the lungs of mice that die at birth

growth/size/body

pulmonary hyperplasia ( J:128019 )

• mice exhibit lung hypercellularity due to a 4-fold increased in proliferation in the lungs

• the lungs of mice that die at birth exhibit a 3-fold increase in the number of neuroendocrine cell clusters in their lungs compared to in wild-type mice