Phenotypes Associated with This Genotype

Genotype
MGI:3811798

• Allelic Composition: Tg(IghMyc)22Bri/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:78177 , J:186117 , J:223213 )

• mice die at 6 to 15 weeks of age with 94% of mice dying by 4 months of age (J:78177)

• median survival is 100 days (J:186117)

neoplasm

increased tumor incidence ( J:78177 )

• mice occasionally develop thyoma without involvement of peripheral lymphoid organs

increased leukemia incidence ( J:78177 )

• mice develop multicentric lymphosarcoma associated with leukemia

increased lymphoma incidence ( J:78177 , J:223213 )

• 13 of 15 mice develop lymphomas (J:78177)

• mice develop multicentric lymphosarcoma associated with leukemia (J:78177)

increased B cell derived lymphoma incidence ( J:78177 , J:186117 )

• lymphomas develop from single B-lymphoid clones at different stages of differentiation (J:78177)

• mutants exhibit a mixture of sIg- pre-B lymphoma (~40%) and sIg+ B lymphoma (~60%) (J:186117)

increased sarcoma incidence ( J:78177 )

• mice develop multicentric lymphosarcoma associated with leukemia

immune system

enlarged thymus ( J:78177 )

enlarged spleen ( J:78177 )

• two-fold

abnormal lymphopoiesis ( J:78177 )

• mice exhibit an increased in the number of lymphoblasts in lymph tissues and the blood compared to wild-type mice

increased leukocyte cell number ( J:186117 )

• white blood cell counts are increased

increased pre-B cell number ( J:223213 )

• bone marrow from 5 week old mice contains an accumulation of pre-B cells

enlarged lymph nodes ( J:78177 )

hematopoietic system

enlarged thymus ( J:78177 )

enlarged spleen ( J:78177 )

• two-fold

abnormal lymphopoiesis ( J:78177 )

• mice exhibit an increased in the number of lymphoblasts in lymph tissues and the blood compared to wild-type mice

increased leukocyte cell number ( J:186117 )

• white blood cell counts are increased

increased pre-B cell number ( J:223213 )

• bone marrow from 5 week old mice contains an accumulation of pre-B cells

endocrine/exocrine glands

enlarged thymus ( J:78177 )

growth/size/body

enlarged spleen ( J:78177 )

• two-fold

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Burkitt lymphoma		DOID:8584	OMIM:113970	J:78177 , J:186117