Analysis Tools
mortality/aging
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• the mean life span of these male mice is 99 days, which is significantly longer than the 88 day mean lifespan that males from this strain normally live
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growth/size/body
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• mice are generally smaller than controls
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immune system
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• increased mast cell numbers are found in the superficial layer of the epidermis, with about a 3-fold increase over controls
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• the characteristic B220+Thy1+ T cells population found in the spleen of mice carrying the Faslps allele is reduced by more than 5-fold in these mice
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hematopoietic system
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• increased mast cell numbers are found in the superficial layer of the epidermis, with about a 3-fold increase over controls
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• the characteristic B220+Thy1+ T cells population found in the spleen of mice carrying the Faslps allele is reduced by more than 5-fold in these mice
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integument
sparse hair
(
J:140028
)
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• pups have scanty growth of short hair on the head and back
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• the number of hair follicles in a given patch of skin appears to be higher than controls but counting is difficult because of the unusual orientation of the follicles
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• axes of hair shafts are randomly oriented, with some being horizontal to the skin layer
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• mice fail to grow vibrissae hairs
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• mice have thick skin with hyperplasia of the epidermis that is prone to injury
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hypotrichosis 6 | DOID:0110703 |
OMIM:607903 |
J:140028 | |
