Phenotypes Associated with This Genotype

Genotype
MGI:3812399

• Allelic Composition: Zeb1^tm1Yhi/Zeb1^tm1Yhi
• Genetic Background: either: (involves: 129 * C3H * C57BL/6) or (involves: 129 * C57BL/6 * ICR)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:139194 )

• half of the mice die within a year from lymphomas

• all mice die by 550 days

neoplasm

increased T cell derived lymphoma incidence ( J:139194 )

• 84% of mice have T cell derived lymphomas that are mostly CD4 single positive T cells

• median onset of disease is 30 weeks after birth with early onset occurring 95 days after birth

• lymphoma cells had invaded various lymph nodes, including the thoracic, peripancreatic, mesenteric, perirenal, mesenteric, and other peripheral lymph nodes

homeostasis/metabolism

ascites ( J:139194 )

• at 4 months of age, 64.3% of mice have enlargement of the abdomen due to ascities fluid

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:139194 )

• 84% of mice have T cell derived lymphomas that are mostly CD4 single positive T cells

• median onset of disease is 30 weeks after birth with early onset occurring 95 days after birth

• lymphoma cells had invaded various lymph nodes, including the thoracic, peripancreatic, mesenteric, perirenal, mesenteric, and other peripheral lymph nodes

immune system

increased T cell derived lymphoma incidence ( J:139194 )

• 84% of mice have T cell derived lymphomas that are mostly CD4 single positive T cells

• median onset of disease is 30 weeks after birth with early onset occurring 95 days after birth

• lymphoma cells had invaded various lymph nodes, including the thoracic, peripancreatic, mesenteric, perirenal, mesenteric, and other peripheral lymph nodes

hematopoietic system

increased T cell derived lymphoma incidence ( J:139194 )

• 84% of mice have T cell derived lymphomas that are mostly CD4 single positive T cells

• median onset of disease is 30 weeks after birth with early onset occurring 95 days after birth

• lymphoma cells had invaded various lymph nodes, including the thoracic, peripancreatic, mesenteric, perirenal, mesenteric, and other peripheral lymph nodes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
tropical spastic paraparesis		DOID:321	OMIM:159580	J:139194