mortality/aging
• 40% of mice survive weaning if littermate competition is removed and the weaning period is extended
|
• mice that survive weaning do not live beyond 250 days
• however, survival can be increased by treatment with rapamycin
|
• mice die rapidly in the first few days of life
• however, lifespan can be increased if littermate competition is removed and the weaning period is extended
|
neoplasm
• 12% of mice develop thyroid tumors with a follicular aspect
|
• 11% of mice exhibit thoracic and abdominal/inguinal mammary gland tumors
• mammary gland tumors exhibit prominent intraluminal and ductal proliferation
• mammary gland tumors ranged from fibroadenomas to adenocarcinomas and ductal carcinomas with dense hyaline collagen or dense fibrosis
|
• mice develop multiple hyperproliferative skin lesions that range from mucocutaneous lesions to tumor formation
|
• mice develop papules around the nose, mouth and eyes
|
endocrine/exocrine glands
• 56% of mice develop multinodular goiters
|
• 12% of mice develop thyroid tumors with a follicular aspect
|
• in 80% of mice
|
• 11% of mice exhibit thoracic and abdominal/inguinal mammary gland tumors
• mammary gland tumors exhibit prominent intraluminal and ductal proliferation
• mammary gland tumors ranged from fibroadenomas to adenocarcinomas and ductal carcinomas with dense hyaline collagen or dense fibrosis
|
integument
• in 80% of mice
|
• 11% of mice exhibit thoracic and abdominal/inguinal mammary gland tumors
• mammary gland tumors exhibit prominent intraluminal and ductal proliferation
• mammary gland tumors ranged from fibroadenomas to adenocarcinomas and ductal carcinomas with dense hyaline collagen or dense fibrosis
|
• at 11 days, the hair shafts have a disheveled appearance unlike in heterozygous mice
|
• hair follicles are increased in size compared to in wild type mice
|
• facial and periauricular lesions involve hyperproliferation of the outer root sheath in the vibrissae
|
• papillomatous lesions of the skin exhibit hyperkeratosis and acanthosis through the face and body skin
|
acanthosis
(
J:138927
)
• papillomatous lesions of the skin exhibit hyperkeratosis and acanthosis through the face and body skin
|
flaky skin
(
J:138927
)
• at 6 days of age
|
skin lesions
(
J:138927
)
• mice develop multiple hyperproliferative skin lesions that range from mucocutaneous lesions to tumor formation
• facial and periauricular lesions involve hyperproliferation of the outer root sheath and vibrissae
• acral extremities areas exhibit verrucous and hyperkeratotic lesions also seen in the punctuate palmoplantar keratosis of the paws
• mice exhibit palmoplantar keratoses, acral keratosis and oral papules
• cutaneous lesions contain trichilemmomas
• however, rapamycin treatment reverses and prevents lesion formation
|
• at 6 days of age
|
• mice develop multiple hyperproliferative skin lesions that range from mucocutaneous lesions to tumor formation
|
• mice develop papules around the nose, mouth and eyes
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Cowden syndrome | DOID:6457 |
OMIM:PS158350 |
J:138927 |