Phenotypes Associated with This Genotype

Genotype
MGI:3813538

• Allelic Composition: Men1^tm1.1Gfk/Men1⁺
• Genetic Background: involves: 129T2/SvEms * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased adrenal gland adenoma incidence ( J:116086 )

• of 11 mice with enlarged adrenals or overt masses in the adrenal 10 had cortical adenomas and 1 had medullary and cortical tumors

increased pituitary adenoma incidence ( J:116086 )

• anterior pituitary microadenoma or adenoma are seen in 77.8% of females and 42% of males over 270 days of age

increased prolactinoma incidence ( J:116086 )

• many of the pituitary adenomas stain positive for prolactin

increased parathyroid adenoma incidence ( J:116086 )

• seen in 6 of 60 heterozygotes over 270 days of age

increased pancreas adenoma incidence ( J:116086 )

• at least 1 pancreatic adenoma was seen in 79.2% of heterozygotes over 270 days of age

increased glucagonoma incidence ( J:116086 )

• a few small islet adenomas with unusual morphology, producing predominately glucagon are found

increased insulinoma incidence ( J:116086 )

• large pancreatic adenomas are almost always insulinomas

increased ovary tumor incidence ( J:116086 )

♀ • ovarian tumors are seen but are less common compared to Leydig cell tumors in males and are rarely bilateral

♀ • histology indicates these are sex cord stromal tumors

increased Leydig cell tumor incidence ( J:116086 )

♂ • Leydig cell tumors are frequently seen in males over 360 days of age and are often bilateral

♂ • histology indicates these are sex cord stromal tumors

endocrine/exocrine glands

increased adrenal gland adenoma incidence ( J:116086 )

• of 11 mice with enlarged adrenals or overt masses in the adrenal 10 had cortical adenomas and 1 had medullary and cortical tumors

abnormal pituitary gland morphology ( J:116086 )

• gross pituitary abnormalities are seen in 91.4% of aged females but only 59.4% of aged males

increased pituitary adenoma incidence ( J:116086 )

• anterior pituitary microadenoma or adenoma are seen in 77.8% of females and 42% of males over 270 days of age

increased prolactinoma incidence ( J:116086 )

• many of the pituitary adenomas stain positive for prolactin

parathyroid gland hyperplasia ( J:116086 )

• seen in 4 of 60 heterozygotes over 270 days of age

increased parathyroid adenoma incidence ( J:116086 )

• seen in 6 of 60 heterozygotes over 270 days of age

thyroid gland hyperplasia ( J:116086 )

• hyperplastic or neoplastic changes are seen more frequently than in controls

abnormal pancreas morphology ( J:116086 )

• about 82% of aged mice display gross pancreatic abnormalities

pancreatic islet hyperplasia ( J:116086 )

• about 17 % of aged mice display marked hyperplasia of the pancreatic islets

• hyperplasia is more severe than that in aged controls

increased pancreas adenoma incidence ( J:116086 )

• at least 1 pancreatic adenoma was seen in 79.2% of heterozygotes over 270 days of age

increased glucagonoma incidence ( J:116086 )

• a few small islet adenomas with unusual morphology, producing predominately glucagon are found

increased insulinoma incidence ( J:116086 )

• large pancreatic adenomas are almost always insulinomas

increased ovary tumor incidence ( J:116086 )

♀ • ovarian tumors are seen but are less common compared to Leydig cell tumors in males and are rarely bilateral

♀ • histology indicates these are sex cord stromal tumors

increased Leydig cell number ( J:116086 )

♂ • frequently seen in males over 360 days of age

♂ • often bilateral

increased Leydig cell tumor incidence ( J:116086 )

♂ • Leydig cell tumors are frequently seen in males over 360 days of age and are often bilateral

♂ • histology indicates these are sex cord stromal tumors

nervous system

abnormal pituitary gland morphology ( J:116086 )

• gross pituitary abnormalities are seen in 91.4% of aged females but only 59.4% of aged males

increased pituitary adenoma incidence ( J:116086 )

• anterior pituitary microadenoma or adenoma are seen in 77.8% of females and 42% of males over 270 days of age

increased prolactinoma incidence ( J:116086 )

• many of the pituitary adenomas stain positive for prolactin

reproductive system

increased ovary tumor incidence ( J:116086 )

♀ • ovarian tumors are seen but are less common compared to Leydig cell tumors in males and are rarely bilateral

♀ • histology indicates these are sex cord stromal tumors

increased Leydig cell number ( J:116086 )

♂ • frequently seen in males over 360 days of age

♂ • often bilateral

increased Leydig cell tumor incidence ( J:116086 )

♂ • Leydig cell tumors are frequently seen in males over 360 days of age and are often bilateral

♂ • histology indicates these are sex cord stromal tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple endocrine neoplasia type 1		DOID:10017	OMIM:131100	J:116086