Phenotypes Associated with This Genotype

Genotype
MGI:3813539

• Allelic Composition: Men1^tm2.1Gfk/Men1⁺
• Genetic Background: involves: 129T2/SvEms * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased pituitary adenoma incidence ( J:116086 )

• anterior pituitary microadenoma or adenoma

increased parathyroid adenoma incidence ( J:116086 )

• seen in 12.5% of mice at or above 540 days of age

increased pancreas adenoma incidence ( J:116086 )

• pancreatic adenomas are seen in 71% of mice at or above 540 days of age adrenal cortical adenomas

• rates of pathologies are not significantly different from those of Men1^tm1.1Gfk heterozygotes

increased insulinoma incidence ( J:116086 )

• predominant type of pancreatic adenoma

increased ovary tumor incidence ( J:116086 )

♀ • similar in pathology to Men1^tm1.1Gfk heterozygotes

increased Leydig cell tumor incidence ( J:116086 )

♂ • similar in pathology to Men1^tm1.1Gfk heterozygotes

endocrine/exocrine glands

abnormal pituitary gland morphology ( J:116086 )

• gross pituitary abnormalities similar in pathology to those of Men1^tm1.1Gfk heterozygotes

increased pituitary adenoma incidence ( J:116086 )

• anterior pituitary microadenoma or adenoma

increased parathyroid adenoma incidence ( J:116086 )

• seen in 12.5% of mice at or above 540 days of age

thyroid gland hyperplasia ( J:116086 )

• hyperplastic or neoplastic changes are seen more frequently than in controls

increased pancreas adenoma incidence ( J:116086 )

• pancreatic adenomas are seen in 71% of mice at or above 540 days of age adrenal cortical adenomas

• rates of pathologies are not significantly different from those of Men1^tm1.1Gfk heterozygotes

increased insulinoma incidence ( J:116086 )

• predominant type of pancreatic adenoma

increased ovary tumor incidence ( J:116086 )

♀ • similar in pathology to Men1^tm1.1Gfk heterozygotes

increased Leydig cell tumor incidence ( J:116086 )

♂ • similar in pathology to Men1^tm1.1Gfk heterozygotes

nervous system

abnormal pituitary gland morphology ( J:116086 )

• gross pituitary abnormalities similar in pathology to those of Men1^tm1.1Gfk heterozygotes

increased pituitary adenoma incidence ( J:116086 )

• anterior pituitary microadenoma or adenoma

reproductive system

increased ovary tumor incidence ( J:116086 )

♀ • similar in pathology to Men1^tm1.1Gfk heterozygotes

increased Leydig cell tumor incidence ( J:116086 )

♂ • similar in pathology to Men1^tm1.1Gfk heterozygotes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple endocrine neoplasia type 1		DOID:10017	OMIM:131100	J:116086