Phenotypes Associated with This Genotype

Genotype
MGI:3814329

• Allelic Composition: Prkn^tm1Ykt/Prkn^tm1Ykt; Tg(Prp-GPR37)1Ryot/0
• Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased dopaminergic neuron number ( J:140326 )

• at 18 months of age, the number of dopamine transporter and VMAT2+ cells is decreased compared to in wild-type mice

neuron degeneration ( J:140326 )

• at 12 months of age, mice exhibit a reduction in the number of TH+ or Nissl staining neurons in the substantia nigra pars compacta and locus ceruleus associated with apoptosis

cellular

abnormal redox activity ( J:140326 )

• at 18 and 24 months, mice exhibit a 30% reduction in mitochondrial complex I activity compared to in wild type mice

oxidative stress ( J:140326 )

• mice exhibit an age-dependent increase in the levels of a marker of oxidative damage in the midbrain region

• however, mice do exhibit oxidative damage in the cortex region

behavior/neurological

behavior/neurological phenotype ( J:140326 )

N • despite loss of dopaminergic neurons, mice exhibit normal behaviors

homeostasis/metabolism

decreased dopamine level ( J:140326 )

• by 24 months

increased dopamine level ( J:140326 )

• in young animals

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 2		DOID:0060368	OMIM:600116	J:140326