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Phenotypes Associated with This Genotype
Genotype
MGI:3814330
Allelic
Composition		 Prkntm1Ykt/Prkntm1Ykt
Tg(PDGFB-GPR37)20Ryot/Tg(PDGFB-GPR37)20Ryot
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkntm1Ykt mutation (0 available); any Prkn mutation (54 available)
Tg(PDGFB-GPR37)20Ryot mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
neuron degeneration ( J:140326 )
• at 12 months of age, mice exhibit a reduction in the number of TH+ or Nissl staining neurons in the substantia nigra pars compacta and locus ceruleus associated with apoptosis

behavior/neurological
behavior/neurological phenotype ( J:140326 )
N
• mice exhibit normal behaviors

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Parkinson's disease 2 DOID:0060368 OMIM:600116
 J:140326

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory