About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3814330
Allelic
Composition		 Prkntm1Ykt/Prkntm1Ykt
Tg(PDGFB-GPR37)20Ryot/Tg(PDGFB-GPR37)20Ryot
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkntm1Ykt mutation (0 available); any Prkn mutation (54 available)
Tg(PDGFB-GPR37)20Ryot mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
neuron degeneration ( J:140326 )
• at 12 months of age, mice exhibit a reduction in the number of TH+ or Nissl staining neurons in the substantia nigra pars compacta and locus ceruleus associated with apoptosis

behavior/neurological
behavior/neurological phenotype ( J:140326 )
N
• mice exhibit normal behaviors

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Parkinson's disease 2 DOID:0060368 OMIM:600116
 J:140326

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory